David Moyes’ side ended a six-game winless run in the top flight and are now only in the bottom three in the rankings based on goal difference.
Arsenal come into the game just one point outside the top four, though they dropped more points at the weekend in a 1-1 draw away at Southampton.
The tie at St Mary’s followed a 3-1 home defeat against Manchester United and the Gunners will be under pressure to return to the capital with a win on Wednesday.
TV CHANNEL & LIVE STREAM
In the UK, the game will be available to watch live on television on BT Sport 1 and BT Sport 4K UHD, or alternatively online using BT Sport app.
In the US, the game will be broadcast live on television on NBC Sports Gold, and available to stream live online using the NBC Sports App.
SQUADS & TEAM NEWS
Cheikhou Kouyate may return to the Hammers squad, having missed the weekend’s 1-0 win over Chelsea.
Javier Hernandez could return to the starting XI, though Moyes may stick with the team which picked up three points in Saturday’s London derby.
Potential starting XI: Adrian; Zabaleta, Reid, Ogbonna, Cresswell, Masuaku; Noble, Obiang; Arnautovic, Lanzini, Antonio
Arsene Wenger has ruled Shkodran Mustafi and Aaron Ramsey out of the game. Jack Wilshere is a potential replacement for Ramsey, while Rob Holding is likely to come into the side in place of Mustafi.
Potential starting XI: Cech; Bellerin, Koscielny, Holding, Monreal, Kolasinac; Xhaka, Wilshere, Ozil, Sanchez; Lacazette.
BETTING & MATCH ODDS
Visitors Arsenal are 8/13 favourites to win according to dabblebet, with West Ham priced at 17/4 to beat the Gunners. A draw is considered a 3/1 bet.
Click here to see all the available markets for the game, including first goalscorer, correct score and more.
GAME PREVIEW
Their defeat to United last weekend ended a run of seven consecutive wins on home turf for Arsenal, and Wenger relied on a stoppage-time equaliser from Olivier Giroud to steal a point from Southampton in the following game.
The draw on the south coast highlighted the Gunners’ patchy away form — Wenger’s side have picked up just two wins from eight on the road, against Burnley and Everton.
Against no side have Arsenal won more away Premier League games than they have against West Ham, however, with their 12 victories the same number against both Everton and Aston Villa.
Wednesday’s clash will be West Ham’s 100th home London derby in the Premier League — they’ve won 36 of their previous 99, drawn 22 and lost 41 — and Moyes will be hopeful of making the occasion with a win.
